Vegetable Forcing in Ohio

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Targeted therapy for breast cancer prevention.

With a better understanding of the etiology of breast cancer, molecularly targeted drugs have been developed and are being testing for the treatment and prevention of breast cancer. Targeted drugs that inhibit the estrogen receptor (ER) or estrogen-activated pathways include the selective ER modulators (tamoxifen, raloxifene, and lasofoxifene) and aromatase inhibitors (AIs) (anastrozole, letrozole, and exemestane) have been tested in preclinical and clinical studies. Tamoxifen and raloxifene have been shown to reduce the risk of breast cancer and promising results of AIs in breast cancer trials, suggest that AIs might be even more effective in the prevention of ER-positive breast cancer. However, these agents only prevent ER-positive breast cancer. Therefore, current research is focused on identifying preventive therapies for other forms of breast cancer such as human epidermal growth factor receptor 2 (HER2)-positive and triple-negative breast cancer (TNBC, breast cancer that does express ER, progesterone receptor, or HER2). HER2-positive breast cancers are currently treated with anti-HER2 therapies including trastuzumab and lapatinib, and preclinical and clinical studies are now being conducted to test these drugs for the prevention of HER2-positive breast cancers. Several promising agents currently being tested in cancer prevention trials for the prevention of TNBC include poly(ADP-ribose) polymerase inhibitors, vitamin D, and rexinoids, both of which activate nuclear hormone receptors (the vitamin D and retinoid X receptors). This review discusses currently used breast cancer preventive drugs, and describes the progress of research striving to identify and develop more effective preventive agents for all forms of breast cancer

Recalibrating the Wide-field Infrared Survey Explorer (WISE) W4 Filter

We present a revised effective wavelength and photometric calibration for the Wide-field Infrared Survey Explorer (WISE) W4 band, including tests of empirically motivated modifications to its pre-launch laboratory-measured relative system response curve. We derived these by comparing measured W4 photometry with photometry synthesised from spectra of galaxies and planetary nebulae. The difference between measured and synthesised photometry using the pre-launch laboratory-measured W4 relative system response can be as large as 0.3 mag for galaxies and 1 mag for planetary nebulae. We find the W4 effective wavelength should be revised upward by 3.3%, from 22.1 micron to 22.8 micron, and the W4 AB magnitude of Vega should be revised from m = 6.59 to m = 6.66. In an attempt to reproduce the observed W4 photometry, we tested three modifications to the pre-launch laboratory-measured W4 relative system response curve, all of which have an effective wavelength of 22.8 micron. Of the three relative system response curve models tested, a model that matches the laboratory-measured relative system response curve, but has the wavelengths increased by 3.3% (or 0.73 micron) achieves reasonable agreement between the measured and synthesised photometry.Comment: Accepted for publication in Publications of the Astronomical Society of Australia, 6 pages, 4 figures, 1 tabl

Method and means for providing an absolute power measurement capability Patent

Input radio frequency circuit for switching type absolute temperature measuring radiometer for noise source

Interquark Potential in Schrodinger Representation

Static charges are introduced in Yang-Mills theory via coupling to heavy fermions. The states containing static color charges are constructed using integration over gauge transformations. A functional representation for interquark potential is obtained. This representation provides a simple criterion for confinement.Comment: 9pp., Late

Zonal Jets as Transport Barriers in Planetary Atmospheres

The connection between transport barriers and potential vorticity (PV) barriers in PV-conserving flows is investigated with a focus on zonal jets in planetary atmospheres. A perturbed PV-staircase model is used to illustrate important concepts. This flow consists of a sequence of narrow eastward and broad westward zonal jets with a staircase PV structure; the PV-steps are at the latitudes of the cores of the eastward jets. Numerically simulated solutions to the quasigeostrophic PV conservation equation in a perturbed PV-staircase flow are presented. These simulations reveal that both eastward and westward zonal jets serve as robust meridional transport barriers. The surprise is that westward jets, across which the background PV gradient vanishes, serve as robust transport barriers. A theoretical explanation of the underlying barrier mechanism is provided. It is argued that transport barriers near the cores of westward zonal jets, across which the background PV gradient is small, are found in Jupiter's midlatitude weather layer and in the Earth's summer hemisphere subtropical stratosphere.Comment: Accepted for publication in JA

Biostimulants in Plant Science: A Global Perspective.

This review presents a comprehensive and systematic study of the field of plant biostimulants and considers the fundamental and innovative principles underlying this technology. The elucidation of the biological basis of biostimulant function is a prerequisite for the development of science-based biostimulant industry and sound regulations governing these compounds. The task of defining the biological basis of biostimulants as a class of compounds, however, is made more complex by the diverse sources of biostimulants present in the market, which include bacteria, fungi, seaweeds, higher plants, animals and humate-containing raw materials, and the wide diversity of industrial processes utilized in their preparation. To distinguish biostimulants from the existing legislative product categories we propose the following definition of a biostimulant as "a formulated product of biological origin that improves plant productivity as a consequence of the novel or emergent properties of the complex of constituents, and not as a sole consequence of the presence of known essential plant nutrients, plant growth regulators, or plant protective compounds." The definition provided here is important as it emphasizes the principle that biological function can be positively modulated through application of molecules, or mixtures of molecules, for which an explicit mode of action has not been defined. Given the difficulty in determining a "mode of action" for a biostimulant, and recognizing the need for the market in biostimulants to attain legitimacy, we suggest that the focus of biostimulant research and validation should be upon proof of efficacy and safety and the determination of a broad mechanism of action, without a requirement for the determination of a specific mode of action. While there is a clear commercial imperative to rationalize biostimulants as a discrete class of products, there is also a compelling biological case for the science-based development of, and experimentation with biostimulants in the expectation that this may lead to the identification of novel biological molecules and phenomenon, pathways and processes, that would not have been discovered if the category of biostimulants did not exist, or was not considered legitimate

A Scintillating Fiber Hodoscope for a Bremstrahlung Luminosity Monitor at an Electron−-Positron Collider

The performance of a scintillating fiber (2mm diameter) position sensitive detector ($4.8 \times 4.8$ cm$^2$ active area) for the single bremstrahlung luminosity monitor at the VEPP-2M electron-positron collider in Novosibirsk, Russia is described. Custom electronics is triggered by coincident hits in the X and Y planes of 24 fibers each, and reduces 64 PMT signals to a 10 bit (X,Y) address. Hits are accumulated (10 kHz) in memory and display (few Hz) the VEPP-2M collision vertex. Fitting the strongly peaked distribution ( $\sim$ 3-4 mm at 1.6m from the collision vertex of VEPP-2M ) to the expected QED angular distribution yields a background in agreement with an independent determination of the VEPP-2M luminosity.Comment: LaTeX with REVTeX style and options: multicol,aps. 8 pages, postscript figures separate from text. Accepted in Review of Scientific Instruments (~ Aug 1996